THE BRAIN LESION OF GOLDTHIOGLUCOSE OBESITY
نویسندگان
چکیده
منابع مشابه
The Brain Lesion of Goldthioglucose Obesity
The development of hypothalamic lesions due to goldthioglucose are described. The initial extensive necrotic lesion occurs in close to 100 per cent of animals injected with LD(50). Within 2 weeks the necrotic material has been removed and a narrow scar results. After a lapse of several months, the scar is often difficult to visualize, especially in animals that have not developed obesity. The v...
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The incidence of hepatomas was markedly increased in goldthioglucose-obese CBA males as compared with nonobese controls. Goldthioglucose-induced obesity did not have as striking an effect on the incidence of liver tumors in females when compared with the males, even though the females weighed more than the treated males. Hepatomas appearing in obese intact females and castrated obese and contro...
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The accumulation of gold in the hypothalamus and the development of hyperphagia and obesity were studied in mice given a single intravenous injection of goldthioglucose at various levels of blood glucose concentration. It was found that the glucose concentration prevailing at the time of goldthioglucose injection was correlated directly with the level of free and bound goldthioglucose in the bl...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1965
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.121.3.395